Ntungamo District was part of the Ankole Kingdom, a traditional monarchy that dates back to the 18th century and was elevated to a district way back in 1993.
Ntungamo District is bordered to the north by Mitooma District, Sheema District and Mbarara District, going from west to east. Isingiro District lies to the east, the Republic of Rwanda to the south, Kabale District to the southwest and Rukungiri District to the northwest.
The district headquarters at Ntungamo, are located about 66 kilometres (41 mi), by road, southwest of Mbarara, the largest city in Ankole sub-region